The 27th International Conference on Genome Informatics (GIW 2016) will be held at Fudan University, Shanghai, China on October 3-5, 2016. The aims of the conference are to present recent results of both theoretical and practical research, to show new applications, to demonstrate systems, and to indicate directions of future research. Papers in all areas related to works that are ultimately devoted to the computational understanding of biological systems on a molecular basis will be considered.