Deadline for application: 23rd of May: https://www.lyyti.fi/reg/Integrative_Structural_Biology_Course_3770

The two week course is a joint effort between the three large-scale research infrastructures SciLifeLab, MAX IV and ESS and additional related platforms. The aim is to give an overview of the structural biology available at the research infrastructures in Sweden. The course will focus on understanding the sample requirements, the nature of structural information that can be obtained and how data from multiple structural biology methods can be combined using e.g. computational chemistry techniques. The course consists of lectures, key note speakers, modelling practicals and facility visits. In addition events allowing time for networking within the group of students, the teachers and other infrastructure personnel, contributing to an expanded professional network.

Technologies/methods:

*Macromolecular X-ray and neutron crystallography
*Small angle X-ray and neutron scattering 
*Cryo-electron microscopy
*Macromolecular nuclear magnetic resonance spectroscopy
*Structural mass spectrometry
*Modelling and Computational methods 
*Biophysical characterization

Keynote speakers:

We proudly present a number of exciting keynote speakers that will present scientific examples of how integrative structural biology techniques can be used to solve intriguing questions.

Professor Poul Nissen, Aarhus University
Professor Carmen Domene, University of Bath
Postdoctoral researcher Hanna Barriga, Karolinska university

Also we will be able to join in on the SciLifeLab “Annual lecture on Structural Biology” where Demis Hassabis will talk on using AI to accelerate scientific discovery.

Lessons on modelling/computational methods:

We will have several lectures on modelling and computational techniques for structural biology.

Associate professor Lucie Delemotte, Integrating physics-based and evolutionary modelling to investigate the conformational dynamics of membrane proteins

Professor Gunnar von Heijne, Different approaches to the study of cotranslational protein folding

Professor Erik Lindahl, titel tbd

Principal Research Engineer Claudio Mirabello, The protein structure prediction problem: from Anfinsen to AlphaFold.