A network biology workflow to study transcriptomics data of the diabetic liver

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Department of Bioinformatics - BiGCaT, Maastricht University

The department of Bioinformatics-BiGCaT is part of NUTRIM the school of Nutrition and Translational Research in Metabolism at Maastricht University, the Netherlands. It was founded in 2001 by Prof. dr. Chris Evelo aiming at employing bioinformatics approaches in systems biology to integrate experimental data and data with current knowledge. Integrative Systems Biology is being developed and applied in various research fields. The department has four core research areas; 1) Metabolic diseases, 2) Micronutrients, 3) Toxicity and risk Assessment and 4) Rare diseases. Within these areas different types of data, like transcriptomics, proteomics, metabolomics and (epi)genomics data, are collected , integrated and combined with existing knowledge

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A network biology workflow to study transcriptomics data of the diabetic liver

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The described network biology workflow uses state-of-the-art pathway and network analysis methods to study the rewiring of the diabetic liver. The integration of experimental data and knowledge on disease-affected biological pathways, including regulatory elements like transcription factors or drugs, leads to improved insights and a clearer illustration of the overall process. It also provides a resource for building new hypotheses for further follow-up studies. The approach is highly generic and can be applied in different research fields.

DOI: 10.1186/1471-2164-15-971

Keywords: Biological networks, Network Visualization

Contributors: Susan Coort, Martina Kutmon, Chris Evelo

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