This is the workflow of homology modelling with the SWISS-MODEL expert system

SWISS-MODEL is a web-based integrated service dedicated to protein structure homology modelling. It guides the user in building protein homology models at different levels of complexity.
Building a homology model comprises four main steps: (i) identification of structural template(s), (ii) alignment of target sequence and template structure(s) - with an extra module on template comparison, (iii) model building and (iv) model quality evaluation. These steps require specialized software and integrate up-to-date protein sequence and structure databases. Each of the above steps can be repeated interactively, until a satisfying modelling result is achieved.

For further information on related topics, please refer to a more general workflow for structure prediction.

DOI: https://doi.org/10.1093/nar/gky427

Keywords: protein structure, Protein structure visualisation, Protein structure analysis, Protein structure databases, Computational modelling, Protein-Protein Complex modeling

Authors: Juergen Haas, Florian Heer

Contributors: SWISS-MODEL team

Scientific topics: Structure prediction, Protein structure analysis, Protein binding sites, Protein folds and structural domains, Structural biology, Structure analysis, Protein interactions