Abstract

Sequence comparison is a core problem in bioinformatics. It is used widely in evolutionary studies, structural and functional analyses, assembly, metagenomics, etc. Despite its regular presence in everyday Life-sciences pipelines, it is still not a trivial step that can be overlooked. Therefore, understanding how sequence comparison works is key to developing efficient workflows that are central to so many other disciplines.

About This Material

This is a Hands-on Tutorial from the GTN which is usable either for individual self-study, or as a teaching material in a classroom.

Questions this will address

• How can we run pairwise genome comparisons using Galaxy?
• How can we run massive chromosome comparisons in Galaxy?
• How can we quickly visualize genome comparisons in Galaxy?

Learning Objectives

• Learn the basics of pairwise sequence comparison
• Learn how to run different tools in Galaxy to perform sequence comparison at fine and coarse-grained levels
• Learn how to post-process your sequence comparisons