e-learning

Mapping and molecular identification of phenotype-causing mutations

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Abstract

In order to map and identify phenotype-causing mutations efficiently from a

About This Material

This is a Hands-on Tutorial from the GTN which is usable either for individual self-study, or as a teaching material in a classroom.

Questions this will address

  • What is mapping-by-sequencing?
  • How can it help you identify the causative mutation in phenotypic mutants isolated from genetic screens?

Learning Objectives

  • Use joint variant calling and extraction to facilitate variant comparison across samples
  • Perform variant linkage analyses for phenotypically selected recombinant progeny
  • Filter, annotate and report lists of variants

Licence: Creative Commons Attribution 4.0 International

Keywords: Variant Analysis

Target audience: Students

Resource type: e-learning

Version: 16

Status: Active

Prerequisites:

  • Introduction to Galaxy Analyses
  • Mapping
  • Quality Control

Learning objectives:

  • Use joint variant calling and extraction to facilitate variant comparison across samples
  • Perform variant linkage analyses for phenotypically selected recombinant progeny
  • Filter, annotate and report lists of variants

Date modified: 2023-11-09

Date published: 2018-03-07

Authors: Wolfgang Maier

Contributors: Björn Grüning, Bérénice Batut, Helena Rasche, Niall Beard, Nicola Soranzo, Saskia Hiltemann, Wolfgang Maier

Scientific topics: Genetic variation

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