Abstract

Neoantigen prediction for HLA binding is a critical component of personalized cancer immunotherapy. Neoantigens, which are tumor-specific antigens resulting from mutations in cancer cells, can be recognized by the immune system, making them promising targets for tailored immunotherapies. Human leukocyte antigen (HLA) molecules play a key role in presenting these neoantigens on the surface of cells, where they can be detected by T-cells, triggering an immune response.

About This Material

This is a Hands-on Tutorial from the GTN which is usable either for individual self-study, or as a teaching material in a classroom.

Questions this will address

• How can we predict the neoantigens presented by tumor cells?
• How does the HLA genotype affect the immune response to cancer?

Learning Objectives

• Predict potential neoantigens based on HLA binding affinity.
• Understand the role of HLA genotyping in predicting personalized immune responses.
• Use specific tools for processing sequence data to predict HLA-binding peptides.