Workshops and courses

ELIXIR node event A guide to identifying and prioritising drug targets with the Open Targets Platform

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Date: 19 May 2021

The Open Targets Platform - https://platform.opentargets.org/ - is a comprehensive research tool that supports systematic identification and prioritisation of potential therapeutic drug targets.‌ By integrating publicly available datasets along with data generated by the Open Targets consortium, the Platform builds and scores target-disease associations. Users can also explore relevant annotation information about targets, diseases, phenotypes, and drugs, as well as their most relevant relationships.

This webinar will provide an overview of the Open Targets Platform which is a freely available resource that is actively maintained with bi-monthly data updates. All data is available through an intuitive user interface, a GraphQL API, and data downloads. Likewise, the pipeline and infrastructure codebases are open-source and can be used to create a self-hosted private instance of the Platform with custom data.

Keywords: Fermentation, Microbial ecosystems webinar, Ensembl Genomes, DNA & RNA (dna-rna), UniProt: The Universal Protein Resource, Proteins (proteins), BLAST, Open Targets Platform, Cross domain (cross-domain), Chemical biology (chemical-biology), Drug discovery, Drug target identification, UniRule, ARBA, Automated annotation, MetaboLights: Metabolomics repository and reference database, Chemical Entities of Biological Interest, ChEBI, Metabolites, Molecular building blocks of life, Human Cell Atlas Data Coordination Platform, Single-cell transcriptomics, HCA data portal, Programmatic access, API, Python, Complex Portal, macromolecular assembly, InterPro, Boolean modelling, Europe PubMed Central, Literature (literature), Open access, Protein Data Bank in Europe - Knowledge Base, 3D structure, AlphaFold Database, DeepMind, Artificial intelligence, AI, Structure prediction, cancer, Boolean, European Nucleotide Archive, Data archive, Raw sequencing data, RNAcentral, Non-coding RNA, ncRNA, GPU, Data protection, Job dispatcher, Bioimage analysis resource, Accessibility, Missense variation, Biostatistics, Rfam, non-coding RNA, Infernal software, Sequence annotation, Root microbiome, Abiotic stress, land management, Plant genotype, Plant webinar series, HPC, database development, cross-linked databases, Plant database, data infrastructure, Plant breeding, Data standards, data managemnet, data sharing, Hyb-Seq method, Flowering plants, Crop improvement, Pangenomics, Pangenomes, Virtual humans, Drug-target identification, plant-microbe interactions, Spatial transcriptomics, Plant research, Drug targets, Machine learning, Mathematical modelling, plant science, Data integration, plant-environment interaction, Phenotyping, field phenotyping, Deep phenotyping, EOSC-Life, NHGRI-EBI GWAS Catalog, clinical data, genome-wide association, Proteomics, Proteomes, Peptide search, plants, European Variation Archive, EVA, Variant clusters, Variant data annotation, Constraint-based metabolic modelling, UniProt knowledgebase, protein variant impact, disease-associated protein variants, Bioethics, FAIR principles, ELSI, cohort data, translational research, BioModels database, Mathematical modeling, Reproducibity, Systems biology models, workflows, federated analysis, polygenic risk scores, IntAct Molecular Interaction Database, PSICQUIC, IMEx, Complex portal, Agent-based modelling, Macrophages, Tumorigenesis, Ensembl, Training (Training), On-demand, teaching, introduction, Building blocks, Data analysis, COSMIC, Cancer mutation, Somatic mutation, ChEMBL: Bioactive data for drug discovery, Chemical compounds, drug-like molecules, Chemogenomics, Biocurator, Programming, Data management, Green Algorithms, Open data, Environmental impact, Carbon footprint, HPC workflows, Orchestrator, Gene expression (gene-expression), Chemosensitivity assay, Experimental protocols, Drug screening, MICHA, European Genome-phenome Archive, EGA, restricted access, UniProt, Introduction, UniProtKB, Proteome, Protein Data Bank in Europe, genes, Introductory, GDPR, Data security, Expression Atlas, Pfam, protein sequence search, Domain architecture, Protein taxonomy, AI structure prediction, COVID-19, Coronavirus, COVID-19 Data Portal, Virology, Computational simulations, Signalling prior knowledge, Cancer therapy response, PRIDE: The Proteomics Identifications Database, protein structure prediction, AI system, Competency framework, Publication, Journal club, Preprints, Aggregated view, Structural similarity, PPI networks, Cell signaling, Malaria, Biological networks, Graph theory, Building biological networks, Biocuration, Information Manager, Industry, Rare-variant, Variant association, SKAT, Sensitive data, Human cohort data, FAIR, Gene Ontology, International Mouse Phenotyping Consortium Portal, Biocurators, biocuration, programming skills, training, career development, Cell-level simulations, Personalised medicine, PerMedCoE, Single cell, Phenotype, Genome-Wide Association Studies, Genome, Signaling networks, BioImage Archive, REST, Funding, UniChem: Chemical Structure Cross-referencing, Bioactivity data, Drug-like compounds, BioStudies Database, EBI Search, Finding data, World Sight Day, Eye development, Eye disease, Open software, Metadata, Web Services, Dbfetch, Database fetch, programmatic access, Open Targets, Protein structure prediction, Colab notebooks, RESTful API, RESTful Web Services, PDBe, Ligand binding sites, Protein families, Protein functional analysis, Protein sequences, Data curation, Biomolecular sequences, Cytoscape, PsyArXiv, Psychology

Organizer: European Bioinformatics Institute (EBI)

Target audience: Plant research, Plant research

Capacity: 500

Event types:

  • Workshops and courses

Scientific topics: Drug discovery

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