The Ensembl project provides a comprehensive and integrated source of annotation of mainly vertebrate genome sequences. Our sister project Ensembl Genomes covers bacteria, plants, fungi, protists and (invertebrate) metazoa. This workshop is aimed at researchers and developers interested in exploring the data beyond the websites. The workshop covers how to use the Ensembl REST APIs, including understanding the major endpoints and how to write Python/R/Perl scripts to call them.