Protein complexes play a crucial role in driving biological functions and processes, making it important to gain insights into proteins and their higher-order assemblies.Complex Portal is a curated resource designed to offer insights into proteins and their higher-level complexes. In this webinar we will introduce the portal, address how we define protein complexes, demonstrate how to search complexes using accession numbers, or keywords specific search, perform organism-specific searches, explore examples of complex details pages including the Complex Viewer and link-outs to related databases. We will also look at the new ‘star-rating’ given to complexes, use the Complex Navigator to compare orthologous and paralogous complexes and introduce the predicted human complexes from huMAP3.0 and MuSIC maps.