The International Mouse Phenotyping Consortium (IMPC) is a resource created by an international collaborative effort from 21 research institutions, aiming to identify the function of every mammalian protein-coding gene using the mouse as a model organism. Currently, the IMPC has generated knockout lines for 8,901 mouse genes, and studied them systematically to determine their function in different biological systems and their role in disease.This webinar will offer an overview of how IMPC data is generated, along with a guided tour of the website, showcasing key features and available data. We will also explore how phenotype data can be used to investigate Mendelian diseases, and how the PhenoDigm algorithm can be applied to identify new models of human disease-gene associations.